General Corona virus updates

Welcome to our Community
Wanting to join the rest of our members? Feel free to Sign Up today.
Sign up

Splinty

Shake 'em off
Admin
Dec 31, 2014
44,116
89,905
So are they working on a good vaccine, or we just gonna ride it out with this shitty one?
Vaccine works perfectly fine for the original strain for which it was designed. Better than other "good" vaccines routinely used.

Even with the lowering effectiveness per the Israeli data above, a 5 time reduction in severe disease would solve my hospital overrun and vent shortage.

Booster shot moves Delta protection to 85%+ as per prelim Israeli data from the coin flip it currently sits.

Second gen vaccines like Curevac will likely offer better more comprehensive coverage. Timeline though dictates that we will be riding out for some period with the existing vaccines.
 

Dick Niaz

Yearning for TMMAC days gone by
Jan 14, 2018
12,278
25,375
There has never been a good vaccine for coronaviruses.
This is false.

Here is a decent summary explanation of how they are effective FOR THEIR INTENDED PURPOSE.

Vaccine efficacy tells us about risk reduction, so people who get vaccinated with the Pfizer or Moderna shots benefit from about a 95% lower risk of developing COVID-19 once exposed compared to those who are not vaccinated. So no, it doesn’t mean vaccinated people have a 5% chance of getting COVID-19 or that 95% of people are protected from the disease.

It’s also important to note the clinical trials did not test whether the vaccines prevented infection in participants. It tested how well the vaccines prevented the development of symptom-causing disease.

“People should be reassured that if they are fully vaccinated that they are very likely, highly likely, to be protected against severe or critical illness, the kind of illness that would cause them to be hospitalized or killed by this virus,” Dr. Paul Offit, a vaccine expert at Children’s Hospital of Philadelphia, told the Post. “Vaccines save your life.”
 

Rambo John J

Baker Team
First 100
Jan 17, 2015
74,723
73,989
This is false.

Here is a decent summary explanation of how they are effective FOR THEIR INTENDED PURPOSE.

Vaccine efficacy tells us about risk reduction, so people who get vaccinated with the Pfizer or Moderna shots benefit from about a 95% lower risk of developing COVID-19 once exposed compared to those who are not vaccinated. So no, it doesn’t mean vaccinated people have a 5% chance of getting COVID-19 or that 95% of people are protected from the disease.

It’s also important to note the clinical trials did not test whether the vaccines prevented infection in participants. It tested how well the vaccines prevented the development of symptom-causing disease.

“People should be reassured that if they are fully vaccinated that they are very likely, highly likely, to be protected against severe or critical illness, the kind of illness that would cause them to be hospitalized or killed by this virus,” Dr. Paul Offit, a vaccine expert at Children’s Hospital of Philadelphia, told the Post. “Vaccines save your life.”
Good sales pitch

Not buying it though, those promises aren't panning out...that ones a dog

I would get into Curevac, hearing big things, can't give specifics but it's going to the moon

1629344104460.png
 

Dick Niaz

Yearning for TMMAC days gone by
Jan 14, 2018
12,278
25,375
Good sales pitch

Not buying it though, those promises aren't panning out...that ones a dog

I would get into Curevac, hearing big things, can't give specifics but it's going to the moon

View attachment 43980
Nah it’s not like that. Certainly not selling anything and would never push an agenda. We don’t need to get into it though. I know how you feel about vaccines. I do imagine that you have an area of expertise that you have dedicated your adult life’s work to though. I would also imagine it would frustrate you to see well-meaning yet completely naive comments from so many uninformed Google experts, like I do. Love ya buddy, but I’m good agreeing to disagree on this one.
 

Rambo John J

Baker Team
First 100
Jan 17, 2015
74,723
73,989
Nah it’s not like that. Certainly not selling anything and would never push an agenda. We don’t need to get into it though. I know how you feel about vaccines. I do imagine that you have an area of expertise that you have dedicated your adult life’s work to though. I would also imagine it would frustrate you to see well-meaning yet completely naive comments from so many uninformed Google experts, like I do. Love ya buddy, but I’m good agreeing to disagree on this one.
I'm not disregarding your post entirely...I was making a joke

But the numbers promised are not panning out, on multiple fronts

As you say, it will be an agree to disagree situation



PS I don't think you know how I feel about vaccines in general...Just this one particular vaccine that skipped important trials and was given a complete pass on liability and an EUA to be offered/forced upon the public
 

Dick Niaz

Yearning for TMMAC days gone by
Jan 14, 2018
12,278
25,375
I'm not disregarding your post entirely...I was making a joke

But the numbers promised are not panning out, on multiple fronts

As you say, it will be an agree to disagree situation



PS I don't think you know how I feel about vaccines in general...Just this one particular vaccine that skipped important trials and was given a complete pass on liability and an EUA to be offered/forced upon the public
Good clarification. Thanks. Also, for what it is worth, while I’m personally wholeheartedly pro the COVID vaccine for public health, I am against mandates and coercion. That we can agree to agree on.

 

Rambo John J

Baker Team
First 100
Jan 17, 2015
74,723
73,989
Good clarification. Thanks. Also, for what it is worth, while I’m personally wholeheartedly pro the COVID vaccine for public health, I am against mandates and coercion. That we can agree to agree on.

100%
My main beef is with the mandates and coercion and the path that those things lead us down.
 

Qat

QoQ
Nov 3, 2015
16,385
22,483
If you want a crystal ball look at what’s to come, keep an eye on Israel.



Key Points:
  • Israel is one of the leading nations for percent of population vaccinated.
  • They have used primarily the Pfizer and maybe the Moderna vaccines, so MRNA.
  • Immunity is waning around 6 to 8 months.
  • Latest data suggests the protection against severe illness in the over 65yes. has fallen as low as 55 percent (though some analysts are challenging that)
  • The unvaccinated 5 to 6 times as likely to end up with severe illness
  • 90% of new infections are in the highly vaccinated over 50 population

A growing segment of experts believe what is happening in Israel and Florida/other pockets in the southeast will also happen in other areas of the US that have been touting how well they have managed the situation compared to those area of the countries who have had the latest outbreaks. The prevailing opinion predicts the northeast will be about three to four weeks behind Florida/southeast. This aligns with the increases in stocking of monoclonal antibody therapeutics that is taking place in many NE health systems as they make preparations For what is to com. Significant increased demand on respiratory inhalers as well. Buckle-up all.
Our experts are saying the older you are, the more likely it is that protection wanes after about 6 months, booster shots in the fall will probably only be giver for older folks.

We will see.
 

BeardOfKnowledge

The Most Consistent Motherfucker You Know
Jul 22, 2015
60,554
56,071
Vaccine works perfectly fine for the original strain for which it was designed. Better than other "good" vaccines routinely used.

Even with the lowering effectiveness per the Israeli data above, a 5 time reduction in severe disease would solve my hospital overrun and vent shortage.

Booster shot moves Delta protection to 85%+ as per prelim Israeli data from the coin flip it currently sits.

Second gen vaccines like Curevac will likely offer better more comprehensive coverage. Timeline though dictates that we will be riding out for some period with the existing vaccines.
Most vaccines don't need to be administered every 6 months. So no, this is not better than other "good" vaccines. Most vaccines also prevent infection as far as I'm aware.
 

Freeloading Rusty

Here comes Rover, sniffin’ at your ass
Jan 11, 2016
26,916
26,589
Miami Beach Couple Arrested in Hawaii for Using Fake Vaccination Cards
 

Dick Niaz

Yearning for TMMAC days gone by
Jan 14, 2018
12,278
25,375
I've received many vaccines in my life. This is the first I've been told needs to be given to me every 6 months. If you can name me others that the average person receives I'm all ears.
Each vaccine is a little different and some even differ between manufacturer offerings. For example, recommendations were to stop using Merck’s shingles vaccine when GlaxoSmithKline’s version was approved due to not only efficacy but duration of coverage. That was attributable to GSK’s novel antigen which boosts immune response conferring long-term protection.

Back to the initial question, take seasonal influenza vaccine. Global surveillance determines the most likely circulating strains for various hemispheres. Those decisions are made ~September the prior year so manufacturers have time to produce ample supply for the following season’s delivery (~August). That is one reason why flu vaccine is recommended annually, but the other reason is waining immunity. Protection is believed to last somewhere between 6-10 months but each individual is different. Even if the strains didn’t change the vaccine would need a booster within that time frame. We have the luxury of having a flu “season” so immunizations can take place in a standard timeframe but if flu was an issue all year long, we would likely go by time since last shot vs seasonally.

Another example is Tetanus. Boosters are needed every 10yrs. There is a Tetanus & Diphtheria (Td) vaccine but about 15 years ago the recommendation was changed to given the booster with TdAp (Tetanus Diptheria and Pertussis) because it was determined Pertussis (aka “Whooping Cough”) immunity is believed to wane within 10-15yrs.

Another would be varicella. That is a recommended vaccine for children but while it protects against chickenpox in children, the reason for the shingles vaccine is given to adults is because of the high potential for dormant varicella activation as adults immune system weakens and shingles is the breakthrough result.


Those are just a few examples but hopefully that helps give some context.
 
Last edited:

Dick Niaz

Yearning for TMMAC days gone by
Jan 14, 2018
12,278
25,375
Each vaccine is a little different and some even differ between disease states. For example, recommendations were to stop using Merck’s shingles vaccine when GlaxoSmithKline’s version was approved due to not only efficacy but duration of coverage. That was attributable to GSK’s novel antigen which boosts immune response conferring long-term protection.

Back to the initial question, take seasonal influenza vaccine. Global surveillance determines the most likely circulating strains for various hemispheres. Those decisions are made ~September the prior year so manufacturers have time to produce ample supply for the following season’s delivery (~August). That is one reason why flu vaccine is recommended annually, but the other reason is warning immunity. Protection is believed to last somewhere between 6-10 months but each individual is different. Even if the strains didn’t change the vaccine would need a booster within that time frame. We have the luxury of having a flu “season” so immunizations can take place in a standard timeframe but if flu was an issue all year long, we would likely go by time since last shot vs seasonally.

Another example is Tetanus. Boosters are needed every 10yrs. There is a Tetanus & Diphtheria (Td) vaccine but about 15 years ago the recommendation was changed to given the booster with TdAp (Tetanus Diptheria and Pertussis) because it was determined Pertussis (aka “Whooping Cough”) immunity is believed to wane within 10-15yrs.

Another would be varicella. That is a recommended vaccine for children but while it protects against chickenpox in children, the reason for the shingles vaccine is given to adults is because of the high potential for dormant varicella activation as adults immune system weakens and shingles is the breakthrough result.


Those are just a few examples but hopefully that helps give some context.
Sorry. I didn’t meant for that to get so long!

TLDR: Vaccines aren’t perfect and don’t necessarily provide protection forever. Each one is different and therefore we can’t often make broad-brush statements about vaccine preventable diseases or the approved vaccines to protect against them (either contracting or lessening severity).
 
Last edited:

BeardOfKnowledge

The Most Consistent Motherfucker You Know
Jul 22, 2015
60,554
56,071
Each vaccine is a little different and some even differ between manufacturer offerings. For example, recommendations were to stop using Merck’s shingles vaccine when GlaxoSmithKline’s version was approved due to not only efficacy but duration of coverage. That was attributable to GSK’s novel antigen which boosts immune response conferring long-term protection.

Back to the initial question, take seasonal influenza vaccine. Global surveillance determines the most likely circulating strains for various hemispheres. Those decisions are made ~September the prior year so manufacturers have time to produce ample supply for the following season’s delivery (~August). That is one reason why flu vaccine is recommended annually, but the other reason is warning immunity. Protection is believed to last somewhere between 6-10 months but each individual is different. Even if the strains didn’t change the vaccine would need a booster within that time frame. We have the luxury of having a flu “season” so immunizations can take place in a standard timeframe but if flu was an issue all year long, we would likely go by time since last shot vs seasonally.

Another example is Tetanus. Boosters are needed every 10yrs. There is a Tetanus & Diphtheria (Td) vaccine but about 15 years ago the recommendation was changed to given the booster with TdAp (Tetanus Diptheria and Pertussis) because it was determined Pertussis (aka “Whooping Cough”) immunity is believed to wane within 10-15yrs.

Another would be varicella. That is a recommended vaccine for children but while it protects against chickenpox in children, the reason for the shingles vaccine is given to adults is because of the high potential for dormant varicella activation as adults immune system weakens and shingles is the breakthrough result.


Those are just a few examples but hopefully that helps give some context.
As I said, 6 months. That's the issue. It's not that you have to get it again, it's that you need to get this every 6 months in perpetuity or society stays in pause. The flu vaccine you mention, yes, has to be reapplied but there's a season as you point out and it's intended to prevent infection.

I'm a big fan of vaccines, but the reality is this covid vaccine kind of sucks.
 

Splinty

Shake 'em off
Admin
Dec 31, 2014
44,116
89,905
It's not that you have to get it again, it's that you need to get this every 6 months in perpetuity or society stays in pause
That's not data supported.
We don't have studies on patient centered outcomes with a booster at 6 months.

A booster results in both immediate viral neutralizing antibodies and increased memory b cells and t cells.
There's every reason to believe that you will continue to have protection against hospitalization and death for some period of time And there's reason to believe that will be long past 6 months. Will it be enough clinically? Will it be enough to move this thing into background risk? Maybe. Depends on number of people getting vaccinated as much as anything. But what we can't say is the absolute that you're saying right now which is not data supported.

A variant would change this. Second generation shots will likely be better.
 

Dick Niaz

Yearning for TMMAC days gone by
Jan 14, 2018
12,278
25,375
As I said, 6 months. That's the issue. It's not that you have to get it again, it's that you need to get this every 6 months in perpetuity or society stays in pause. The flu vaccine you mention, yes, has to be reapplied but there's a season as you point out and it's intended to prevent infection.

I'm a big fan of vaccines, but the reality is this covid vaccine kind of sucks.
Absolutely there are many new and unique challenges with these initial COVID vaccines. Think about it though, we have been working to develop vaccines for certain diseases for DECADES without success. These vaccines were developed in less than a year - it’s a miracle we have anything at this point. There will be next generation vaccines to be sure, but we will be playing catch-up for a significant period of time before we will be able to have a vaccine which conveys universal protection against COVID-19.