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Yossarian

Yossarian

TMMAC Addict
Oct 25, 2015
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https://nypost.com/2020/04/01/why-is-china-bullying-taiwan-in-the-middle-of-the-global-pandemic/

Meanwhile, Beijing has insisted on keeping Taiwan out of World Health Organization work on the COVID-19 outbreak — even though the island managed to do a fantastic job of containing the virus.

'The world needs Taiwan': Coronavirus pandemic gives beleaguered island a chance to turn tables on China

Taiwan’s ability to donate millions of face masks to the United States and other nations allows the beleaguered island government to use the coronavirus pandemic to resist Chinese pressure, diplomatic sources say.

China sees chance to expand global influence amid pandemic

China is seeking to expand its global influence during the coronavirus pandemic by painting itself as a powerful benefactor at a time when Beijing is facing accusations of concealing information about the initial outbreak.

After this virus, the next crisis is already in the making.
 
MMAHAWK

MMAHAWK

Real Gs come from California.America Muthafucker
Feb 5, 2015
15,226
33,196
Yossarian said:
https://nypost.com/2020/04/01/why-is-china-bullying-taiwan-in-the-middle-of-the-global-pandemic/

Meanwhile, Beijing has insisted on keeping Taiwan out of World Health Organization work on the COVID-19 outbreak — even though the island managed to do a fantastic job of containing the virus.

'The world needs Taiwan': Coronavirus pandemic gives beleaguered island a chance to turn tables on China

Taiwan’s ability to donate millions of face masks to the United States and other nations allows the beleaguered island government to use the coronavirus pandemic to resist Chinese pressure, diplomatic sources say.

China sees chance to expand global influence amid pandemic

China is seeking to expand its global influence during the coronavirus pandemic by painting itself as a powerful benefactor at a time when Beijing is facing accusations of concealing information about the initial outbreak.

After this virus, the next crisis is already in the making.
Click to expand...
 
BeardOfKnowledge

BeardOfKnowledge

The Most Consistent Motherfucker You Know
Jul 22, 2015
60,643
56,167
So these are quotes from a guy who makes reseaches vaccines as a profession:

Joe Rogan: (16:44)
That’s great. Now let’s talk about treatments that are being considered. We know that Z-Pak’s are one of them, and chloroquine. Can you explain that and what went horribly wrong with the couple that took the wrong kind of chloroquine and it turned out to be a koi pond cleaner?

Dr. Hotez: (17:04)
Okay. So let me give you the framework for that so it makes some sense. When we talk about all the interventions, you have things that are going to be ready down the line, things are going to be ready a little closer and things ready now. So and then we can talk about one and then I’ll … let me give you the framework then I’ll answer your chloroquine question.

Dr. Hotez: (17:25)
So the highest bar there is in terms of financial investment required, and time to show safety, is a vaccine. So that’s what we’re doing and other groups are doing. Next tier down, that’s going to be a year, 18 months away, according to Dr. Fauci, could be longer than that. Next tier down are what we call small molecule drugs, new drugs that have never been discovered before. Still takes a while, maybe not as high a bar as vaccine in terms of time. The next tier down is re-purposing existing medicines that we already know are relatively safe and then showing-

Dr. Hotez: (18:03)
Now are relatively safe and then showing that those drugs also work against the Coronavirus and that’s going to be the [inaudible 00:18:08] category, and I’ll get to your question and then the nearest ones, the one that we could do now is what’s called this convalescent antibody therapy, which I’ve been pushing very hard on because I think we can actually have it going right now. So let’s do the chloroquine hydroxychloroquine. This is, and that’s one of the repurposed ones. That’s not the lowest hanging fruit, but the next lowest hanging fruit. This is a medicine that’s used for malaria. It’s an anti-malarial drug. It’s been around for decades. In fact, the World Health Organization was going to had in the 1960s proposed an elimination strategy for malaria to treat everybody with chloroquine until we had chloroquine resistance and that derailed that.

Dr. Hotez: (18:53)
But in some parts of the world, it’s still works as an anti-malarial drug. It’s also used as an antiinflammatory drug for the tree treatment of lupus and other autoimmune diseases. You can make a bucket of it. It’s cheap. We know the safety profile. We know it can cause arrhythmias in some patient and other toxicities, but it generally has a pretty good safety profile. We know that this drug can block the replication of the virus in the test tube, so it inhibits the virus in what we call it, in vitro in the test tube. Second, we know this drug reduces inflammation and that’s nice because one of the things you get with COVID-19 pneumonia is you not only get the virus infection in the lung, you got a lot of inflammation, so it checks a couple of boxes in terms of why it’s attractive to look at it.

Dr. Hotez: (19:43)
And then the Chinese did a small study and then a colleague of mine is a fascinating guy. I really appreciate his work as a scientist. He’s a very serious scientist in Marsay in France named [inaudible 00:19:59] and he’s, I don’t know, must’ve published at least two or three dozen papers in the journal that I founded call Plus Neglected Tropical Diseases. He’s a serious scientist, works on all sorts of intracellular bacteria and that kind of thing. Tick borne diseases, did a small study showing that it worked in COVID patients. And what he did was he combined hydroxychloroquine with the Z-Pak, the Zithromycin drug and found that there’s an effect. The problem was that it was a very tiny study and so people put those three things together and all of a sudden said we’ve got the miracle cure. I’m not sure that’s going to turn out to be the case.

Dr. Hotez: (20:36)
I mean we really need to do large studies to show that it really works. And the reason I’m holding back is nothing to do with Dr. Professor O is a really important scientists, but it’s a small study. We were there about a decade ago with influenza that this hydroxychloroquine also inhibited the influenza virus in the test tube. But then it didn’t pan out in larger clinical studies. So I think we have to be really careful and don’t be too quick to say, “Okay, this is going to be it.” We’re not even close to that yet, but we’ll know in the next few weeks because we’re working hard to scale up clinical trials looking at that medicine.
Click to expand...
 
Splinty

Splinty

Shake 'em off
Admin
Dec 31, 2014
44,116
89,915
ConorMcGregorsBeard said:
So these are quotes from a guy who makes reseaches vaccines as a profession:
Click to expand...
Let's put some context to that since that was a little while ago right?

To my knowledge as of this week...

Chinese study was a news briefing. They still haven't published anything. That is there is no study. Just a press conference. This is the origin of the main focus on using this for covid19, beyond the fact that the drug has been experimented with for influenza and other viruses (incidentally with poor outcomes)

French study had an outcome of viral shedding. Not clinical condition. It was all about 30 people and not randomized anyway. But even ignoring that it didn't have anything to do with patient clinical improvement.

Every other study is in vitro. Not vivo.

Ivermectin also shows in vitro activity. So does bleach. So does anything else that will kill the virus...

The French study suggests that we may see some benefit in contagiousness. And in the end there might very well be some clinical benefit. But there's not a single study powered for that yet that's been published. That is to say there is zero data that hydroxychloroquine improves patient-centered outcomes.


A Chinese study attempted to do what the French say did but also use patient centered outcomes. they also randomized themselves which the French study did not. So this is a better study in the sense of statistics and also because they're trying to look at patient centered outcomes like fever or radiographic improvement in pneumonias, etc.

A pilot study of hydroxychloroquine in treatment of patients with common coronavirus disease-19 (COVID-19)

The result? There was no improvement in the hydroxychloroquine group.

once again these are not large multicentered randomized trials which is the real standard in medicine. And the lack of evidence doesn't prove We won't find which patients this might work in.
But it does mean there's currently a lack of evidence. Literally no patient-centered outcome trials show benefit right now.
Just showing pneumonia improvement or fever resolution or hypoxia improvement is all you'd have to show. And we haven't done that yet.
 
ThatOneDude

ThatOneDude

Commander in @Chief, Dick Army
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Jan 14, 2015
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I heard that rinsing your sinuses with orange juice kills the Corona19 virus because orange juice is acidic.

Anyone tried this?
 
BeardOfKnowledge

BeardOfKnowledge

The Most Consistent Motherfucker You Know
Jul 22, 2015
60,643
56,167
Splinty said:
Let's put some context to that since that was a little while ago right?
Click to expand...
That was on Tuesday of this week. Dr Peter Hotez is out of Baylor I believe. He was talking quite a bit about Houston. You should take the hour or so an listen to it.
 
Splinty

Splinty

Shake 'em off
Admin
Dec 31, 2014
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ConorMcGregorsBeard said:
That was on Tuesday of this week. Dr Peter Hotez is out of Baylor I believe. He was talking quite a bit about Houston.
Click to expand...
maybe I heard him saying the same thing on a different podcast a couple weeks ago. I recognize his name and the same statements. I only watched Joe Rogan when you tell me to
 
Chief

Chief

4070 = Legend
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Jan 14, 2015
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ThatOneDude said:
I heard that rinsing your sinuses with orange juice kills the Corona19 virus because orange juice is acidic.

Anyone tried this?
Click to expand...
I sniff salt water when I feel a throat tingle. Usually stops it in its tracks.
 
BeardOfKnowledge

BeardOfKnowledge

The Most Consistent Motherfucker You Know
Jul 22, 2015
60,643
56,167
Splinty said:
maybe I heard him saying the same thing on a different podcast a couple weeks ago. I recognize his name and the same statements. I only watched Joe Rogan when you tell me to
Click to expand...
It's just over an hour, he talks about Houston. Check it out:

 
Papi Chingon

Papi Chingon

Domesticated Hombre
Oct 19, 2015
27,387
34,272
Splinty said:
Could you link me to one of those studies
Click to expand...
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. - PubMed - NCBI
This could be the same study
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial - ScienceDirect


https://www.mediterranee-infection.com/wp-content/uploads/2020/03/COVID-IHU-2-1.pdf

Quantifying treatment effects of hydroxychloroquine and azithromycin for COVID-19: a secondary analysis of an open label non-randomized clinical trial (Gautret et al, 2020)
 
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