Yes
This noodle-armed little faggot was able to choke one to death after it attacked him. If he can do it, a 70 year old Asian grandma could do it, too. A Mexican Abuela would drop a mountain lion midair with one of her flip-flops.
Meet the Man Who Strangled a Mountain Lion
Watch Travis Kauffman describe the incident in his own wordswww.outsideonline.com
Not the size of lion I am envisioning
That article says it is a 30+ lion that had only vegetation in it's belly
I'm thinking of a 100-150+ experienced killer all jacked up, but that type of lion probably prefers elk to human.