2 fresh UFC title fights in a row surely can't happen.
I'm predicting Overeem gets injured/USADAed, JDS is the only viable replacement, JDS wins, JDS v Cain 4 is signed, Cain wins, Cain is signed to fight in Mexico City 12 months later, gets injured, fights the interim holder 12 months after that, and eventually we have a non-rematch title fight sometime in 2022.