General Corona virus updates

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MartyLife

ยาเม็ดสีแดงหรือสีฟ้ายา?
Feb 7, 2020
1,840
1,623
I friggen looooove swords and castles and ish. But I've always had an unhealthy disdain for royalty since I live in lala land where my heroes are usually the lowborn, bastards, and broken men. So I never tune into an royal ish since I know I'm gonna get triggered

Ohhhh you meant the old ladies corona thing today? I actually added that to my watch later when I got the pop up. It autoplayed at one point and I quickly Xed out

Shes cute, so I felt bad actually lol. Couodnt do it


Three lions on a shirt. Jewels remain still gleaming
I think the Queen making her statement yesterday was because .....She knew the UK might not have a PM for much longer.
Now he's in ICU. methinks she was heading off the panic after being told he was in trouble.

Namaste
 

FINGERS

Banned
Nov 14, 2019
17,004
19,804
I think the Queen making her statement yesterday was because .....She knew the UK might not have a PM for much longer.
Now he's in ICU. methinks she was heading off the panic after being told he was in trouble.

Namaste

Nah. It was timed for a Sunday always.

her schedule is always two weeks in advance.

Johnson pegging it means nothing to us. He is seen as a fool. We won’t mourn him too much. He was a pm in name only.

he is not a details guy. His tenure as mayor of London was a joke.

I care more if an ambulance or bus driver person who contracts the virus than him.

not wishing death upon him of course.

but he is a useless twat
 

Splinty

Shake 'em off
Admin
Dec 31, 2014
44,116
89,915
This is the first study published that I have seen (still not peer reviewed but whatev, neither was the french study) that shows a benefit in clinical outcome. That's a good beginning, though its still early.

Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial

5 days after enrollment or severe adverse reactions appeared was the observation endpoint. Changes in time to clinical recovery (TTCR) and clinical characteristics of patients were evaluated after administration. TTCR is defined as the return of body temperature and cough relief, maintained for more than 72 h. Normalization and mitigation criteria included the following: a. Body temperature ≤ 36.6 °C on the surface, ≤ 37.2 °C under the armpit and mouth or ≤ 37.8 °C in the rectum and tympanic membrane; b. Cough from patients’ reports, slight or no cough was in the asymptomatic range. Body temperature, cough check three times daily to calculate the average level. For radiological changes, the chest CT results in one day before (Day 0) and one day after (Day 6) the study for evaluation. Pulmonary recovery is defined as three levels: exacerbated, unchanged, and improved, moderately improved when less than 50 % of pneumonia were absorbed, and more than 50 % means significantly improved
Result:

Code:
Fever, day (SD)a 2.6 (1.0) 3.2 (1.3) 2.2 (0.4) 0.0008

Cough, day (SD)b  2.4 (1.1) 3.1 (1.5) 2.0 (0.2) 0.0016

Progressed to severe illness 4 (6.5 %) 4 (12.9 %) 0

Adverse effects 2 (3.2 %) 0 2 (6.4 %)
Fever better 1 day sooner
Cough better 1.2 day sooner
No progression to severe illness
Adverse effects seen in 2/31 HCQ patients = rash and headache.
 

Splinty

Shake 'em off
Admin
Dec 31, 2014
44,116
89,915
The same reason they listen to Splinty @Splinty .
We're beacons of light in an otherwise grim society.
Like math class, I always try to show my work for peer review.
COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism

There is some question of oxygen dissociation curve changes such as a viral mediated hemoglobinopathy.
This does not match many cases and is only seen in this lab. It may be true in the subsect of cases presenting as "happy hypoxic" patients. But it doesn't match those patients perfectly either. Microemboli is suspected by the US hematology groups who are saying to trial anti coagulation in many patients with some basic criteria.


As such, we are seeing a potential phenotype division and with it treatment modalities might come for different presentations.

So called L and H type is the first proposed differences by Dr. Gattinoni that authored the original paper that your medium post is refrencing ( https://www.atsjournals.org/doi/abs/10.1164/rccm.202003-0817LE )

Here is his followon:
https://www.esicm.org/wp-content/uploads/2020/04/684_author-proof.pdf